Department of Chemistry & Biochemistry

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Research

Student-faculty collaborative research is one of our programmatic strengths. Including analytical, physical, organic, inorganic and biochemistry projects, our faculty engage students in diverse and interdisciplinary research topics.

Students pursuing the American Chemical Society-approved major complete one year of undergraduate research.

Dr. Cassidy Dobson - biochemistry

Dr. Dobson's research is focused on Biochemistry. She is working on determining the mechanism of a particular chaperone protein called DBF (disulfide bond forming enzyme).  This chaperone is responsible for refolding cysteine-rich disulfide bond containing proteins. Disulfide bonds are unique in proteins structure in that they are controlled by redox conditions and are not an interaction, but a bond between cysteine residues. Generally, chaperones that assist in disulfide bond formation themselves have cysteine residues in order to facilitate rearrangement of the incorrectly made disulfide bonds. DBF does not contain any cysteine residues and is very different from other disulfide isomerases. We seek to determine the mechanism of action of DBF and apply its chaperoning abilities to disulfide bond forming aggregates such as those found in cataracts; disulfide-mediated aggregates of gamma-crystallin proteins. 

Dr. Michael Dvorak - analytical chemistry

My research interests are based on the practical application of fluorescence and luminescence techniques for the detection and quantification of select species in mixtures. This can take on either a theoretical or experimental application. On the theoretical side, our goal is to develop simple, matrix-based algorithms that can model the spectroscopic response from the components of a mixture. The results are compared with experimental results to determine the validity of the model. On the experimental side, we use pulsed (laser based) and non-pulsed (traditional lamp) techniques to generate fluorescence lifetimes (pulsed mode) or fluorescence signatures (lamp) from species on surfaces, species separated via chromatographic techniques, or species intrinsic to a mixture.

Other projects include establishing a Resonance Enhanced Multiphoton Ionization (REMPI) workstation for ultratrace detection of aromatic species in the gas phase. I am also involved in understanding the nature of dative bonding via several techniques including IR grazing angle and possibly Surface Enhanced Raman Spectroscopy (SERS) on self assembled monolayers, gas phase IR in a supersonic slit expansion (in collaboration with the U of MN), and fluorescence signatures of select B-N species in solution phase.

My work requires a “hands-on” aptitude to work with chemical instrumentation and to trouble-shoot experimental methodology. Although programming skills are not necessary, students desiring to develop programming skills are especially welcome. I believe that students ultimately interested in graduate or post- SCSU activities in a physical/analytical laboratory are a good fit for my lab.

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Dr. Thomas G. Gardner - metal-organic materials synthesis

My research students and I study the incorporation of aromatic macrocyclic metal complexes such as phthalocyanines and porphyrins into 1-, 2- and 3-D macromolecular structures in a way that allows for collective and interactive effects to develop between these light-sensitive, electrically conductive rings, with the hope of yielding materials with properties interesting to catalytic, molecular electronic, photoconductive, solar energy, and photodynamic therapy applications.

Dr. Mohammad Hossain - organic and biological chemistry

Fig 1: The sequential alkylations of cellular thiols by 3,5-bis(arylidene)-4-piperidones leading to the cell death of neoplasms.One of my major research interests is the design and synthesis of conjugated α,β-unsaturated ketones as candidate chemotherapeutic agents. These compounds have an exclusive or preferential affinity for reacting with thiols rather than with hydroxyl groups and amines. Since the latter two groups but not thiols are found in nucleic acids, α,β-unsaturated ketones may be devoid of the genotoxic side effects of various anticancer drugs. In particular, recent emphasis has been placed on developing compounds containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore (Fig 1). This group permits sequential alkylation of thiols at the alkene carbon atoms.  This successive attack may lead to tumour-selective toxicity since various studies revealed that after an initial chemical insult, some tumours are more sensitive to a further toxic effect than various nonmalignant cells.

Fig 2: Synthesis of Benzofurans Using Alkyne Functionalization Method.Another interest of my research is to develop a new reaction methodology for synthesizing highly functionalized heterocyclic compounds using alkyne functionalization method (Fig 2). Heterocyclic compounds represent a large group of biologically active compounds, which attract the attention of chemists from all around the world. In particular, the synthesis of functionalized benzofurans is an active area of research in the current literatures because of their remarkable biological activities in many natural products and pharmacophores in drug discovery. Although there are many published methodologies, the development of convenient, efficient, and atom economical synthetic methodologies for the rapid construction of the functionalized benzofurans is still highly desirable.

Dr. Michael Jeannot - analytical chemistry

We are investigating simple microextraction techniques capable of performing trace analysis on environmental or biological samples. In particular, we are developing and applying a technique called solvent microextraction in which a microliter of extracting solvent is suspended from the tip of a syringe needle in the headspace above (or directly immersed in) an aqueous sample. Volatile or semi-volatile organic compounds (pollutants such as chloroform and benzene) are preconcentrated in the microdrop, which is then analyzed by gas chromatography-mass spectrometry or other techniques. Current and future research in this area includes: application of the technique to new analytical problems of interest, and investigation of the mass transfer kinetics of the headspace (3-phase) system.

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Dr. Rebecca Krystyniak - chemistry education

Areas of interest include investigating students' conceptual understanding of ionic compounds at the particulate level, the effects of the order of chemistry content instruction on student understanding, and student understanding of the language of chemistry and how that relates to symbolic representations of molecules and compounds.  I also am working on a project to investigate student understanding and ability to draw Lewis Dot Structures. 

Many of my research interests revolve around inquiry and its implementation into the classroom and the laboratory.  I am interested in reforming the undergraduate laboratory experience to include both guided- and open-inquiry activities.  Part of this process would include developing instruments to measure learning outcomes of these inquiry activities.  I am also interested in incorporating research-based inquiry-focused pedagogy into the Preparatory Chemistry course.

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Dr. Tamara Leenay - organic chemistry

Research interests are in synthetic organic chemistry and outreach development.

Dr. Jack McKenna - physical chemistry

Current research topics include:

  1. Analysis of codeine in poppy seed muffins by GC-MS.
  2. Photochemically induced reactions using laser pointers.
  3. Growth of "large" crystals for a macro-crystalography demonstration.
  4. Development of a technique for the recovery of silver for a CHEM 210 experiment.
  5. Analysis of the fire hazard in the copper-to-silver-to-gold demonstration.
  6. A modification of the "glowing pickle" demonstration.
  7. Development of an NMR equilibrium/kinetics laboratory for pchem.
  8. Development of an NMR experiment on the hydration of aspirin.
  9. Modification of general chemistry experiments to be more "discovery-based."
  10. Development of novel chemical demonstrations.

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Dr. Mark Mechelke - organic chemistry

One strategy in cancer treatment is the development of drugs that will selectively induce apoptosis in tumor cells.  The ability of cancer cells to avoid apoptosis and continue to proliferate is one of the key steps in cancer development.  One potential source for new chemotherapeutic agents is natural products.  Natural products and synthetic derivatives of natural products make up over 60 percent of all cancer drugs used today.  

GoniothalaminFor example, we are working on the natural product goniothalamin, which comes from the dried stem bark of trees and shrubs from the goniothalamus genus.  In preliminary studies, goniothalamin has exhibited low micromolar IC50 values against a variety of different cancer cell lines.  These IC50 values illustrate that goniothalamin’s structure could potentially be used as a template for chemotherapeutic drug design.  A better understanding of goniothalamin’s mechanism of action might lead to the synthesis of derivatives that demonstrate even more potent cytotoxicity. 

The research in my laboratory is directed toward the design and synthesis of novel natural product analogues that will exhibit lower IC50 values against cancer cell lines than the natural product itself.  By making hypotheses on the natural products’ mechanism of action, we design analogues by altering the steric and/or electronic properties of the natural product to make it more biologically active.  The ultimate goal in this research is to design compounds that are more effective in inducing apoptosis in cancer cells and therefore more potent chemotherapeutic agents.

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Dr. Sarah Petitto - physical surface chemistry

Physical surface chemistry of metal oxides, with interdisciplinary research with physics and materials science, focusing primarily the composition and speciation of aquatic systems influenced by chemical processes occurring at the solid-solution interface to develop a detailed understanding of the influence of bulk composition and structure, surface orientation, and interaction of water and other surface modifying solutes on the structure and reactivity at the mineral-fluid interface

Dr. Latha Ramakrishnan - biochemistry, pharmacology, neuroscience

Neurotransmitter-gated receptor proteins mediate communication between ~ 100 billion neurons in the brain. These membrane-bound proteins are critical for the fundamental brain functions, such as memory and learning, and play key roles in the regulation of cell excitability. Many neurological and neuromuscular diseases affect the functions of the neurotransmitter-gated receptor proteins. My primary research interest is to understand the basic molecular mechanisms by which these ion channel proteins work in health and disease states.

The specific ligand-gated ion channel (LGIC) protein that I am interested in is the gamma-aminobutyric acid type A (GABAA) receptor protein. GABAA proteins are one of the sub types of the major inhibitory neurotransmitter-gated ion channel proteins. The investigations in the lab focus on understanding the evolution, function, and expression of this class of proteins in an invertebrate model organism (Planaria). Planarians, the non-parasitic flatworms, are an emerging model organism in regeneration and pharmacology research and are enjoying recent renewed interest as an unique invertebrate model organism in many frontiers of research. We are interested in investigating the behavioral and biochemical pharmacology of the GABAergic proteins in planaria using simple behavioral assays to chromatographic experiments to understand the complex biochemistry of these worms.

The long-term goal of our research is to understand the evolution, expression, and function of GABAerig proteins in planaria. To this end, we will use bioinformatics to investigate the evolution of this class of protein molecules, polymeric nanoparticles to probe the expression of the proteins, and electrophysiology to study the function of the cloned protein molecules in expression systems such as oocytes or mammalian cell lines.

Dr. Nathan Winter - biochemistry

For his 2014-2015 sabbatical project, Dr. Winter has been making freely available, on-line, Biochemistry lecture notes. You can see his lectures here: http://repository.stcloudstate.edu/do/discipline_browser/articles?discipline_key=1